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KMID : 0617220000110010029
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Duksung Bulletin Phamaceutical Sciences
2000 Volume.11 No. 1 p.29 ~ p.33
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Effect of Glycerin on the Skin Permeation of a Model Drug, Nicotinic Acid
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Cho Ae-Ri
Leam Hyunju
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Abstract
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The effects of glycerin (propane-1,2,3-triol) on percutaneous absorption of a model drug, nicotinic acid (NA) through hairless mouse skin were investigated. The major objective of this study was to investigate how the hydration property of glycerin either in the donor solution facing stratum corneum or in the receptor fluid facing dermis skin can influence the skin permeation profile of a drug. The steady state skin permeation rates of NA were evaluated using Valia-Chien diffusion cells and analyzed using HPLC. Saturated solutions of NA in different concentrations of glycerin aqueous solutions (0∼50％) were prepared to maintain the thermodynamic activity in donor solutions equal. In another sets of experiment, saturated solution of NA in 40％ PEG aq. solution was employed as a donor solution and different concentrations of glycerin were employed as a receptor solution. Glycerin in receptor solution facing dermis side significantly influence the skin permeation rate of NA and the enhancement was concentration dependent. The steady state skin permeation rate showed the highest in 10％ and lowest in 50％ (19.25 vs 2.59 ㎍/㎠hr). The enhancement effect of glycerin in donor solution showed similar profile but less significantly (6.39 vs 2.71 ㎍/㎠/hr). There were good correlation between hydration property of the skin and the steady state skin flux. As hydration increased, the steady state flux increased. The enhancement of the hydration was more significant with glycerin in the receptor solution facing dermis side as compared with those in the donor solution facing the stratum corneum side. These results suggest that hydration property of glycerin can influence the skin permeation rate quite extensively and the permeation through the tissues containing high water such as dermis can be influenced significantly by the presence of glycerin. High diffusivity induced by the hydration effect of glycerin could be the major contributing factor for the enhanced skin permeation.
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